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KMID : 0606920140220060558
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Biomolecules & Therapeutics
2014 Volume.22 No. 6 p.558 ~ p.562
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Dependence Potential of Tramadol: Behavioral Pharmacology in Rodents
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Cha Hye-Jin
Song Min-Ji
Lee Kwang-Wook
Kim Eun-Jung
Kim Young-Hoon
Lee Yun-Je
Seong Won-Keun
Hong Sa-Ik
Jang Choon-Gon
Yoo Han-Sang
Jeong Ho-Sang
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Abstract
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Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.
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KEYWORD
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Tramadol, Dopamine system, Serotonin system, Drug dependence, Animal behavioral tests
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